For research use only. Not for therapeutic Use.
PROTAC BRD4 ligand-1(CAT: I017562) is a synthetic small-molecule designed as a functional binding element for bromodomain-containing protein 4 (BRD4), a member of the BET (bromodomain and extraterminal) protein family. By incorporating this ligand into PROTAC (proteolysis-targeting chimera) constructs, BRD4 can be selectively recruited to an E3 ubiquitin ligase, promoting targeted degradation via the proteasome. BRD4 regulates transcriptional control, chromatin remodeling, and oncogenic signaling, making it a critical target in cancer, inflammation, and cardiovascular disease research. PROTAC BRD4 ligand-1 is an essential building block for chemical biology and drug discovery efforts in epigenetics and targeted protein degradation.
| CAS Number | 2313230-51-0 |
| Synonyms | 8-(3,5-difluoropyridin-2-yl)-15-methyl-4-(methylsulfonylmethyl)-14-oxo-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaene-5-carboxylic acid |
| Molecular Formula | C23H18F2N4O5S |
| Purity | ≥95% |
| IUPAC Name | 8-(3,5-difluoropyridin-2-yl)-15-methyl-4-(methylsulfonylmethyl)-14-oxo-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaene-5-carboxylic acid |
| InChI | InChI=1S/C23H18F2N4O5S/c1-28-9-16-15-3-11(10-35(2,33)34)14(23(31)32)5-18(15)29(21-17(25)4-13(24)7-27-21)8-12-6-26-20(19(12)16)22(28)30/h3-7,9,26H,8,10H2,1-2H3,(H,31,32) |
| InChIKey | BSYGSSMAXOMCQE-UHFFFAOYSA-N |
| SMILES | CN1C=C2C3=C(C=C(C(=C3)CS(=O)(=O)C)C(=O)O)N(CC4=CNC(=C42)C1=O)C5=C(C=C(C=N5)F)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
