PROTAC BRD4 Degrader-8

• CAT Number: I044618
• Molecular Formula: C53H61F2N9O11S2
• Molecular Weight: 1102.23
• Purity: ≥95%
• Synonyms: 8-(3,5-difluoropyridin-2-yl)-N-[2-[2-[2-[2-[[(2S)-1-[(2S,4R)-4-hydroxy-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-2-oxoethoxy]ethoxy]ethoxy]ethyl]-15-methyl-4-(methylsulfonylmethyl)-14-oxo-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaene-5-carboxamide
• InChI: InChI=1S/C53H61F2N9O11S2/c1-30-46(76-29-60-30)32-9-7-31(8-10-32)21-59-50(68)42-19-36(65)25-64(42)52(70)47(53(2,3)4)61-43(66)27-75-16-15-74-14-13-73-12-11-56-49(67)37-20-41-38(17-33(37)28-77(6,71)72)39-26-62(5)51(69)45-44(39)34(22-57-45)24-63(41)48-40(55)18-35(54)23-58-48/h7-10,17-18,20,22-23,26,29,36,42,47,57,65H,11-16,19,21,24-25,27-28H2,1-6H3,(H,56,67)(H,59,68)(H,61,66)/t36-,42+,47-/m1/s1
• InChIKey: GPZQCKOJSPAJES-KFRCLFBHSA-N
• SMILES: CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)COCCOCCOCCNC(=O)C4=CC5=C(C=C4CS(=O)(=O)C)C6=CN(C(=O)C7=C6C(=CN7)CN5C8=C(C=C(C=N8)F)F)C)O

PROTAC BRD4 Degrader-8（Cat No.:I044618）is a bifunctional small molecule designed to selectively target and degrade BRD4, a member of the BET (bromodomain and extra-terminal) protein family involved in transcriptional regulation of oncogenes. It functions via the PROTAC (Proteolysis Targeting Chimera) mechanism, linking a BRD4-binding ligand to an E3 ligase recruiter, facilitating ubiquitination and subsequent proteasomal degradation of BRD4. This targeted degradation approach offers superior efficacy over traditional inhibition, resulting in sustained suppression of BRD4 activity. PROTAC BRD4 Degrader-8 is valuable for studying epigenetic regulation and advancing anti-cancer therapeutic research.