PROTAC BRD4 Degrader-12

• CAT Number: I044590
• CAS Number: 2417370-90-0
• Molecular Formula: C62H77F2N9O12S4
• Molecular Weight: 1306.58
• Purity: ≥95%
• Synonyms: [(3R,5S)-1-[(2S)-2-[11-[[8-(3,5-difluoropyridin-2-yl)-15-methyl-4-(methylsulfonylmethyl)-14-oxo-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaene-5-carbonyl]amino]undecanoylamino]-3,3-dimethylbutanoyl]-5-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]pyrrolidin-3-yl] 3-methylsulfonylsulfanylbutan-2-yl carbonate
• InChI: InChI=1S/C62H77F2N9O12S4/c1-36-54(86-35-69-36)40-21-19-39(20-22-40)28-68-58(76)50-26-44(85-61(79)84-37(2)38(3)87-89(9,82)83)32-73(50)60(78)55(62(4,5)6)70-51(74)18-16-14-12-10-11-13-15-17-23-65-57(75)45-27-49-46(24-41(45)34-88(8,80)81)47-33-71(7)59(77)53-52(47)42(29-66-53)31-72(49)56-48(64)25-43(63)30-67-56/h19-22,24-25,27,29-30,33,35,37-38,44,50,55,66H,10-18,23,26,28,31-32,34H2,1-9H3,(H,65,75)(H,68,76)(H,70,74)/t37?,38?,44-,50+,55-/m1/s1
• InChIKey: RTGMFKZUBIYNLA-TXWUOVCNSA-N
• SMILES: CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)CCCCCCCCCCNC(=O)C4=CC5=C(C=C4CS(=O)(=O)C)C6=CN(C(=O)C7=C6C(=CN7)CN5C8=C(C=C(C=N8)F)F)C)OC(=O)OC(C)C(C)SS(=O)(=O)C

PROTAC BRD4 Degrader-12（Cat No.:I044590）is a bifunctional molecule designed to selectively degrade BRD4, a member of the BET protein family involved in transcriptional regulation and cancer progression. It harnesses PROTAC (Proteolysis Targeting Chimera) technology, linking a BRD4-binding ligand to an E3 ligase recruiter, inducing ubiquitination and proteasomal degradation of BRD4. This targeted protein degradation approach disrupts oncogenic transcriptional programs more effectively than traditional inhibitors. PROTAC BRD4 Degrader-12 has shown potent activity in preclinical cancer models, offering a promising therapeutic strategy for BRD4-dependent malignancies, including hematological cancers and solid tumors.