PROTAC BRD4 Degrader-11

• CAT Number: I044591
• Molecular Formula: C61H75F2N9O12S4
• Molecular Weight: 1292.56
• Purity: ≥95%
• Synonyms: [(3R,5S)-1-[(2S)-2-[11-[[8-(3,5-difluoropyridin-2-yl)-15-methyl-4-(methylsulfonylmethyl)-14-oxo-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaene-5-carbonyl]amino]undecanoylamino]-3,3-dimethylbutanoyl]-5-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]pyrrolidin-3-yl] [(2R)-2-methylsulfonylsulfanylpropyl] carbonate
• InChI: InChI=1S/C61H75F2N9O12S4/c1-36(86-88(8,81)82)33-83-60(78)84-43-25-49(57(75)67-27-38-18-20-39(21-19-38)53-37(2)68-35-85-53)72(31-43)59(77)54(61(3,4)5)69-50(73)17-15-13-11-9-10-12-14-16-22-64-56(74)44-26-48-45(23-40(44)34-87(7,79)80)46-32-70(6)58(76)52-51(46)41(28-65-52)30-71(48)55-47(63)24-42(62)29-66-55/h18-21,23-24,26,28-29,32,35-36,43,49,54,65H,9-17,22,25,27,30-31,33-34H2,1-8H3,(H,64,74)(H,67,75)(H,69,73)/t36-,43-,49+,54-/m1/s1
• InChIKey: XFVLGTSZPLRRLI-HXMREKMRSA-N
• SMILES: CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)CCCCCCCCCCNC(=O)C4=CC5=C(C=C4CS(=O)(=O)C)C6=CN(C(=O)C7=C6C(=CN7)CN5C8=C(C=C(C=N8)F)F)C)OC(=O)OC[C@@H](C)SS(=O)(=O)C

PROTAC BRD4 Degrader-11（Cat No.:I044591）is a potent bifunctional molecule engineered to induce selective degradation of BRD4, a key BET family protein implicated in cancer and inflammation. Utilizing PROTAC technology, it links a BRD4-binding moiety with an E3 ligase ligand, promoting ubiquitination and subsequent proteasomal degradation of BRD4. This mechanism offers enhanced and sustained suppression of BRD4 activity compared to conventional inhibitors. PROTAC BRD4 Degrader-11 has demonstrated strong efficacy in preclinical studies, making it a valuable research tool and potential therapeutic candidate for BRD4-driven cancers and other transcriptionally dysregulated diseases.