PROTAC BRD4 Degrader-10

• CAT Number: I044592
• CAS Number: 2417370-49-9
• Molecular Formula: C59H71F2N9O15S4
• Molecular Weight: 1312.50
• Purity: ≥95%
• Synonyms: [(3R,5S)-1-[(2S)-2-[[2-[2-[2-[2-[[8-(3,5-difluoropyridin-2-yl)-15-methyl-4-(methylsulfonylmethyl)-14-oxo-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaene-5-carbonyl]amino]ethoxy]ethoxy]ethoxy]acetyl]amino]-3,3-dimethylbutanoyl]-5-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]pyrrolidin-3-yl] 3-methylsulfonylsulfanylbutan-2-yl carbonate
• InChI: InChI=1S/C59H71F2N9O15S4/c1-33-51(86-32-66-33)37-12-10-36(11-13-37)24-65-55(73)47-22-41(85-58(76)84-34(2)35(3)87-89(9,79)80)28-70(47)57(75)52(59(4,5)6)67-48(71)30-83-19-18-82-17-16-81-15-14-62-54(72)42-23-46-43(20-38(42)31-88(8,77)78)44-29-68(7)56(74)50-49(44)39(25-63-50)27-69(46)53-45(61)21-40(60)26-64-53/h10-13,20-21,23,25-26,29,32,34-35,41,47,52,63H,14-19,22,24,27-28,30-31H2,1-9H3,(H,62,72)(H,65,73)(H,67,71)/t34?,35?,41-,47+,52-/m1/s1
• InChIKey: FUFQNGIGEJGHCG-YDIRMPGESA-N
• SMILES: CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)COCCOCCOCCNC(=O)C4=CC5=C(C=C4CS(=O)(=O)C)C6=CN(C(=O)C7=C6C(=CN7)CN5C8=C(C=C(C=N8)F)F)C)OC(=O)OC(C)C(C)SS(=O)(=O)C

PROTAC BRD4 Degrader-10（Cat No.:I044592）is a targeted protein degrader designed to eliminate BRD4, a bromodomain-containing protein involved in regulating oncogenic transcription. It employs PROTAC (Proteolysis Targeting Chimera) technology, combining a BRD4-binding ligand with an E3 ubiquitin ligase recruiter to trigger BRD4 degradation via the proteasome. Unlike traditional inhibitors, this approach results in sustained depletion of BRD4 protein, offering superior efficacy in disrupting BET-dependent gene expression. PROTAC BRD4 Degrader-10 has shown promising results in cellular assays and preclinical cancer models, supporting its use in studying epigenetic regulation and developing cancer therapeutics.