PROTAC BRD4-binding moiety 1

• CAT Number: I015438
• CAS Number: 2101200-10-4
• Molecular Formula: C23H21N3O2
• Molecular Weight: 371.43
• Purity: ≥95%
• Synonyms: 6-(3,5-dimethyl-1,2-oxazol-4-yl)-1-methyl-4-phenyl-3-prop-2-ynyl-4H-quinazolin-2-one
• InChI: InChI=1S/C23H21N3O2/c1-5-13-26-22(17-9-7-6-8-10-17)19-14-18(21-15(2)24-28-16(21)3)11-12-20(19)25(4)23(26)27/h1,6-12,14,22H,13H2,2-4H3
• InChIKey: ZKJVDZJHVLJOKO-UHFFFAOYSA-N
• SMILES: CC1=C(C(=NO1)C)C2=CC3=C(C=C2)N(C(=O)N(C3C4=CC=CC=C4)CC#C)C

PROTAC BRD4-binding moiety 1（Cat No.:I015438）is a small-molecule ligand designed to selectively bind bromodomain-containing protein 4 (BRD4), a member of the BET protein family involved in transcriptional regulation and epigenetics. As a modular building block, it is commonly used in the development of proteolysis-targeting chimeras (PROTACs) to induce BRD4 degradation via the ubiquitin–proteasome pathway. Researchers employ this moiety to explore targeted protein degradation strategies, study BRD4-dependent transcription, and develop therapeutic candidates for cancer and inflammatory diseases. It is a key tool in chemical biology and drug discovery.