For research use only. Not for therapeutic Use.
PROTAC Axl Degrader 2（Cat No.:I043882）is a targeted protein degrader designed to selectively degrade Axl, a receptor tyrosine kinase involved in cancer progression, immune response, and metastasis. By utilizing the PROTAC technology, it recruits an E3 ligase to induce the ubiquitination and degradation of Axl through the proteasomal pathway. This degradation disrupts Axl signaling, which is critical for tumor survival and immune evasion. PROTAC Axl Degrader 2 holds significant potential in cancer therapy, particularly in treating tumors that exhibit high Axl expression and resistance to conventional therapies.
| Synonyms | N-[[4-[[5-amino-1-(6-phenylpyridazin-3-yl)-1,2,4-triazol-3-yl]amino]phenyl]methyl]-6-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]amino]hexanamide |
| Purity | ≥95% |
| IUPAC Name | N-[[4-[[5-amino-1-(6-phenylpyridazin-3-yl)-1,2,4-triazol-3-yl]amino]phenyl]methyl]-6-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]amino]hexanamide |
| InChI | InChI=1S/C38H39N11O4/c39-37-44-38(47-49(37)32-19-17-29(45-46-32)25-8-3-1-4-9-25)42-26-15-13-24(14-16-26)22-41-33(50)12-5-2-6-21-40-30-11-7-10-27-28(30)23-48(36(27)53)31-18-20-34(51)43-35(31)52/h1,3-4,7-11,13-17,19,31,40H,2,5-6,12,18,20-23H2,(H,41,50)(H,43,51,52)(H3,39,42,44,47) |
| InChIKey | OXOOPNYJFVRNCT-UHFFFAOYSA-N |
| SMILES | C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3NCCCCCC(=O)NCC4=CC=C(C=C4)NC5=NN(C(=N5)N)C6=NN=C(C=C6)C7=CC=CC=C7 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
