PROTAC AR Degrader-4 TFA

• CAT Number: I045619
• Molecular Formula: C45H68F3N3O11
• Molecular Weight: 884.03
• Purity: ≥95%
• Synonyms: [(5S,8R,9S,10S,13S,14S,17S)-10,13-dimethyl-3-oxo-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl] 2-[2-[2-[2-[[(2S)-2-[[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]amino]-4-methylpentanoyl]amino]ethoxy]ethoxy]ethoxy]acetate;2,2,2-trifluoroacetic acid
• InChI: InChI=1S/C43H67N3O9.C2HF3O2/c1-28(2)24-36(46-41(51)39(49)35(44)25-29-8-6-5-7-9-29)40(50)45-18-19-52-20-21-53-22-23-54-27-38(48)55-37-13-12-33-32-11-10-30-26-31(47)14-16-42(30,3)34(32)15-17-43(33,37)4;3-2(4,5)1(6)7/h5-9,28,30,32-37,39,49H,10-27,44H2,1-4H3,(H,45,50)(H,46,51);(H,6,7)/t30-,32-,33-,34-,35+,36-,37-,39-,42-,43-;/m0./s1
• InChIKey: URZFPFDMMGLCJC-AFGPOOCPSA-N
• SMILES: CC(C)CC(C(=O)NCCOCCOCCOCC(=O)OC1CCC2C1(CCC3C2CCC4C3(CCC(=O)C4)C)C)NC(=O)C(C(CC5=CC=CC=C5)N)O.C(=O)(C(F)(F)F)O

PROTAC AR Degrader-4 TFA (Cat No.: I045619) is a bifunctional molecule designed to selectively degrade the androgen receptor (AR) through the proteolysis-targeting chimera (PROTAC) approach. It consists of an AR ligand linked to an E3 ubiquitin ligase recruiter, promoting ubiquitination and proteasomal degradation of AR. This compound is widely used in prostate cancer research to study androgen receptor signaling, drug resistance, and targeted protein degradation strategies. The trifluoroacetate (TFA) salt improves solubility and handling, making it suitable for biochemical and cellular studies.

Reference

[1]. Itoh Y, et al. Design, synthesis and biological evaluation of nuclear receptor-degradation inducers. Bioorg Med Chem. 2011 Nov 15;19(22):6768-78.
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