Prostaglandin E2

• CAT Number: R009261
• CAS Number: 363-24-6
• Molecular Formula: C20H32O5
• Molecular Weight: 352.51
• Purity: ≥95%
• Synonyms: (5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic Acid; 7-[3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl]-5-heptenoic Acid; (-)-Prostaglandin E2; (15S)-Prostaglandin E2; Cervidil; Cerviprime; Cerviprost; Dinoprostone; Minprostin E2; P
• Target: Endogenous Metabolite
• Solubility: Soluble in DMSO > 10 mM
• Storage: Store at -20C
• IUPAC Name: (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid
• InChI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1
• InChIKey: XEYBRNLFEZDVAW-ARSRFYASSA-N
• SMILES: CCCCC[C@@H](/C=C/[C@H]1[C@@H](CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O)O

Prostaglandin E₂ (CAT: R009261) is a naturally occurring bioactive lipid and one of the most abundant prostaglandins in mammalian systems. Derived from arachidonic acid via the cyclooxygenase (COX) pathway, PGE₂ plays a central role in inflammation, pain, fever regulation, and vascular homeostasis. It exerts its effects through binding to four G-protein–coupled receptors (EP1–EP4), enabling diverse physiological responses including immune modulation, angiogenesis, gastrointestinal protection, and reproductive processes. In research, PGE₂ is extensively studied in cancer biology, immunology, neurology, and cardiovascular disease, making it an essential mediator for understanding both normal physiology and pathological mechanisms.