Propyphenazone

• CAT Number: I003682
• CAS Number: 479-92-5
• Molecular Formula: C14H18N2O
• Molecular Weight: 230.31
• Purity: ≥95%
• Target: COX
• Solubility: DMSO: ≥ 2.6 mg/mL
• Storage: Room Temperature
• IUPAC Name: 1,5-dimethyl-2-phenyl-4-propan-2-ylpyrazol-3-one
• InChI: InChI=1S/C14H18N2O/c1-10(2)13-11(3)15(4)16(14(13)17)12-8-6-5-7-9-12/h5-10H,1-4H3
• InChIKey: PXWLVJLKJGVOKE-UHFFFAOYSA-N
• SMILES: CC1=C(C(=O)N(N1C)C2=CC=CC=C2)C(C)C

Propyphenazone（Cat No.:I003682） is a derivative of pyrazolone that exhibits anti-inflammatory, analgesic, and antipyretic properties. It acts as a non-selective inhibitor of cyclooxygenase enzymes, thereby reducing the production of inflammatory mediators. Propyphenazone and its analogues are being investigated as prodrugs and selective cyclooxygenase-2 (COX-2) inhibitors, aiming to provide targeted anti-inflammatory effects with reduced side effects compared to traditional nonsteroidal anti-inflammatory drugs (NSAIDs).

Reference

[1]. Radwan MF, et al. Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors. ACS Med Chem Lett. 2014 Jun 23;5(9):983-8.