Propargyl Tosylate

• CAT Number: R039731
• CAS Number: 6165-76-0
• Molecular Formula: C10H10O3S
• Molecular Weight: 210.25
• Purity: ≥95%
• Synonyms: 2-Propyn-1-ol 4-Methylbenzenesulfonate; 2-Propyn-1-ol p-Toluenesulfonate; 1-[(p-Toluenesulfonyl)oxy]-2-propyne; 2-Propynyl p-Toluenesulfonate; 2-Propynyl Tosylate; Propargyl Alcohol Tosylate; p-Toluenesulfonic Acid Propargyl Ester
• Storage: 4°C
• IUPAC Name: prop-2-ynyl 4-methylbenzenesulfonate
• InChI: InChI=1S/C10H10O3S/c1-3-8-13-14(11,12)10-6-4-9(2)5-7-10/h1,4-7H,8H2,2H3
• InChIKey: LMBVCSFXFFROTA-UHFFFAOYSA-N
• SMILES: CC1=CC=C(C=C1)S(=O)(=O)OCC#C

Propargyl tosylate(CAT: R039731) is an organic compound featuring a propargyl group (HC≡C–CH₂–) linked to a tosylate (p-toluenesulfonate) ester. This structure makes it a highly reactive alkylating agent, commonly used in organic synthesis for introducing propargyl functionality into alcohols, amines, and other nucleophiles. The terminal alkyne enables further transformations such as click chemistry (CuAAC) and metal-catalyzed coupling reactions, while the tosylate group acts as a good leaving group, facilitating efficient substitution. Widely applied in medicinal chemistry, materials science, and bioconjugation, propargyl tosylate is a key building block for molecular modification.