For research use only. Not for therapeutic Use.
Propargyl-PEG3-t-butyl ester（Cat No.:I014608）is a compound consisting of a propargyl group, a polyethylene glycol (PEG) linker with three ethylene glycol units (PEG3), and a t-butyl ester group. The propargyl group can undergo click chemistry reactions, such as the copper-catalyzed azide-alkyne cycloaddition (CuAAC), making it useful for conjugation in chemical biology and drug delivery applications. The PEG3 segment enhances water solubility and stability, while the t-butyl ester group provides protection during synthesis and can be cleaved under specific conditions. This compound is often employed in the development of bioconjugates, targeted therapies, and molecular imaging agents.
| CAS Number | 1374658-84-0 |
| Synonyms | Propargyl-PEG3-t-butyl ester;Propargyl-PEG3-t-butyl ester |
| Molecular Formula | C14H24O5 |
| Purity | ≥95% |
| Target | PROTAC Linkers |
| Solubility | Soluble in DMSO |
| IUPAC Name | tert-butyl 3-[2-(2-prop-2-ynoxyethoxy)ethoxy]propanoate |
| InChI | InChI=1S/C14H24O5/c1-5-7-16-9-11-18-12-10-17-8-6-13(15)19-14(2,3)4/h1H,6-12H2,2-4H3 |
| InChIKey | JCKIGUAOHLRKLH-UHFFFAOYSA-N |
| SMILES | CC(C)(C)OC(=O)CCOCCOCCOCC#C |
| Reference | </br>1: Sano K, Nakajima T, Miyazaki K, Ohuchi Y, Ikegami T, Choyke PL, Kobayashi H. Short PEG-linkers improve the performance of targeted, activatable monoclonal antibody-indocyanine green optical imaging probes. Bioconjug Chem. 2013 May 15;24(5):811-6. doi: 10.1021/bc400050k. Epub 2013 May 3. PubMed PMID: 23600922; PubMed Central PMCID: PMC3674550. </br>2: Harrison E, Coulter JA, Dixon D. Gold nanoparticle surface functionalization: mixed monolayer versus hetero bifunctional peg linker. Nanomedicine (Lond). 2016 Apr;11(7):851-65. Review. PubMed PMID: 27021417.</br>3: Augusto MT, Hollmann A, Porotto M, Moscona A, Santos NC. Antiviral Lipopeptide-Cell Membrane Interaction Is Influenced by PEG Linker Length. Molecules. 2017 Jul 15;22(7). pii: E1190. doi: 10.3390/molecules22071190. PubMed PMID: 28714870; PubMed Central PMCID: PMC5776016.</br>4: Tuma R, Russell M, Rosendahl M, Thomas GJ Jr. Solution conformation of the extracellular domain of the human tumor necrosis factor receptor probed by Raman and UV-resonance Raman spectroscopy: structural effects of an engineered PEG linker. Biochemistry. 1995 Nov 21;34(46):15150-6. PubMed PMID: 7578129. </br> </br> |
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