Propargyl-PEG2-MS

• CAT Number: I014606
• CAS Number: 943726-01-0
• Molecular Formula: C8H14O5S
• Molecular Weight: 222.26
• Purity: ≥95%
• Synonyms: 2-(2-prop-2-ynoxyethoxy)ethyl methanesulfonate
• InChI: InChI=1S/C8H14O5S/c1-3-4-11-5-6-12-7-8-13-14(2,9)10/h1H,4-8H2,2H3
• InChIKey: CNUSDGRUYDRKPO-UHFFFAOYSA-N
• SMILES: CS(=O)(=O)OCCOCCOCC#C

Propargyl-PEG2-MS(CAT: I014606) is a heterobifunctional polyethylene glycol (PEG) linker featuring a terminal propargyl (alkyne) group and a methanesulfonate (mesyl, MS) leaving group, connected by a two-unit PEG spacer. The propargyl group enables copper-catalyzed or strain-promoted azide–alkyne cycloaddition (“click chemistry”), while the mesyl group undergoes nucleophilic substitution with thiols, amines, or other nucleophiles. The PEG2 spacer imparts hydrophilicity, flexibility, and reduced steric hindrance, ensuring efficient conjugation in aqueous and organic systems. Propargyl-PEG2-MS is particularly useful in bioconjugation, surface modification, polymer functionalization, and PROTAC development, allowing dual reactivity and controlled molecular spacing in chemical biology and advanced material science.