Propargyl-PEG2-Boc

• CAT Number: I014601
• CAS Number: 1807503-80-5
• Molecular Formula: C12H20O4
• Molecular Weight: 228.28
• Purity: ≥95%
• Synonyms: tert-butyl 3-(2-prop-2-ynoxyethoxy)propanoate
• InChI: InChI=1S/C12H20O4/c1-5-7-14-9-10-15-8-6-11(13)16-12(2,3)4/h1H,6-10H2,2-4H3
• InChIKey: DPARWKDJMUCBKM-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)CCOCCOCC#C

Propargyl-PEG2-Boc (Cat No.: I014601) is a bifunctional chemical building block featuring a terminal propargyl group for copper-catalyzed azide–alkyne cycloaddition (CuAAC) “click” chemistry, a PEG2 spacer (two ethylene glycol units) for enhanced solubility and flexibility, and a Boc-protected amine for selective deprotection and further conjugation. The PEG2 linker minimizes steric hindrance and improves aqueous compatibility, making it suitable for bioconjugation, drug development, and materials science. Propargyl-PEG2-Boc is commonly used in synthesizing multifunctional molecules, including PROTACs, imaging probes, and targeted delivery systems in chemical biology research.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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