Propargyl-PEG12-OH

• CAT Number: I017220
• CAS Number: 1036204-61-1
• Molecular Formula: C27H52O13
• Molecular Weight: 584.69
• Purity: ≥95%
• Synonyms: 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
• InChI: InChI=1S/C27H52O13/c1-2-4-29-6-8-31-10-12-33-14-16-35-18-20-37-22-24-39-26-27-40-25-23-38-21-19-36-17-15-34-13-11-32-9-7-30-5-3-28/h1,28H,3-27H2
• InChIKey: FLGCCIHLPCYSCV-UHFFFAOYSA-N
• SMILES: C#CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO

Propargyl-PEG12-OH(CAT: I017220) is a linear polyethylene glycol (PEG) linker featuring a terminal propargyl (alkyne) group and a terminal hydroxyl group, making it a versatile building block for click chemistry and advanced bioconjugation strategies. The PEG12 spacer enhances solubility, flexibility, and biocompatibility while minimizing steric hindrance, enabling efficient coupling with biomolecules, drugs, or surfaces. Propargyl-PEG12-OH is widely applied in the synthesis of antibody-drug conjugates (ADCs), PROTACs, nanomaterials, and surface modifications. Through copper-catalyzed azide–alkyne cycloaddition (CuAAC), it reacts efficiently with azide-functionalized molecules, offering precise control in chemical biology, medicinal chemistry, and materials science research.