Propargyl-PEG1-SS-PEG1-acid

• CAT Number: I016129
• CAS Number: 1807503-85-0
• Molecular Formula: C10H16O4S2
• Molecular Weight: 264.36
• Purity: ≥95%
• Synonyms: 3-[2-(2-prop-2-ynoxyethyldisulfanyl)ethoxy]propanoic acid
• InChI: InChI=1S/C10H16O4S2/c1-2-4-13-6-8-15-16-9-7-14-5-3-10(11)12/h1H,3-9H2,(H,11,12)
• InChIKey: OEMFYMUYWYWVRT-UHFFFAOYSA-N
• SMILES: C#CCOCCSSCCOCCC(=O)O

Propargyl-PEG1-SS-PEG1-acid（Cat No.:I016129）is a cleavable heterobifunctional linker designed for bioconjugation and controlled release strategies. It features a terminal propargyl group for click chemistry reactions with azides, a carboxylic acid for amide bond formation with primary amines, and a central disulfide (SS) bond that enables redox-sensitive cleavage. The short PEG1 spacers improve solubility and flexibility while minimizing steric hindrance. This reagent is particularly valuable in constructing reversible conjugates, drug delivery systems, and chemical biology tools, where precise, cleavable, and orthogonal functionalization is required for targeted applications.