Prexigebersen sodium

• CAT Number: I040300
• Molecular Formula: C177H206N63Na18O110P17
• Molecular Weight: 5916.25
• Purity: ≥95%

Prexigebersen sodium(CAT: I040300) is an antisense oligonucleotide inhibitor that targets and downregulates Grb2 (growth factor receptor-bound protein 2), a key adaptor protein involved in multiple oncogenic signaling pathways, including RAS/MAPK and PI3K/AKT. By suppressing Grb2 expression, Prexigebersen disrupts downstream signaling critical for cancer cell proliferation and survival. It has shown particular promise in hematologic malignancies such as acute myeloid leukemia (AML), where it enhances sensitivity to chemotherapeutic agents. The sodium salt form improves solubility and pharmacokinetic properties, making it suitable for systemic delivery in research settings. Prexigebersen sodium is a valuable tool for cancer biology and targeted therapy investigations.