PPTN hydrochloride

• CAT Number: I045633
• CAS Number: 1992047-65-0
• Molecular Formula: C29H25ClF3NO2
• Molecular Weight: 511.96
• Purity: ≥95%
• Synonyms: 4-(4-piperidin-4-ylphenyl)-7-[4-(trifluoromethyl)phenyl]naphthalene-2-carboxylic acid;hydrochloride
• InChI: InChI=1S/C29H24F3NO2.ClH/c30-29(31,32)25-8-5-19(6-9-25)22-7-10-26-23(15-22)16-24(28(34)35)17-27(26)21-3-1-18(2-4-21)20-11-13-33-14-12-20;/h1-10,15-17,20,33H,11-14H2,(H,34,35);1H
• InChIKey: FKMVYPCBLWYNAV-UHFFFAOYSA-N
• SMILES: C1CNCCC1C2=CC=C(C=C2)C3=C4C=CC(=CC4=CC(=C3)C(=O)O)C5=CC=C(C=C5)C(F)(F)F.Cl

PPPTN hydrochloride (Cat No.: I045633) is a selective antagonist of the P2X7 receptor, an ATP-gated ion channel implicated in inflammation, immune responses, and cell death. By blocking P2X7 activity, PPTN hydrochloride reduces downstream signaling events such as inflammasome activation and cytokine release. Researchers use it to investigate the role of purinergic signaling in neuroinflammation, pain, autoimmune diseases, and cancer. Its specificity provides a reliable tool for probing P2X7-mediated pathways. While not approved for therapeutic use, PPTN hydrochloride is valuable in biomedical and pharmacological research.

Reference

[1]. Barrett MO, et al. A selective high-affinity antagonist of the P2Y14 receptor inhibits UDP-glucose-stimulated chemotaxis of human neutrophils. Mol Pharmacol. 2013 Jul;84(1):41-9.
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[2]. Lin J, et al. The P2Y14 receptor in the trigeminal ganglion contributes to the maintenance of inflammatory pain. Neurochem Int. 2019 Dec;131:104567.
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