PPC-NB

• CAT Number: I046043
• CAS Number: 1887040-81-4
• Molecular Formula: C15H14N2O5S2
• Molecular Weight: 366.41
• Purity: ≥95%
• Synonyms: (4-nitrophenyl) 2-(pyridin-2-yldisulfanyl)propyl carbonate
• InChI: InChI=1S/C15H14N2O5S2/c1-11(23-24-14-4-2-3-9-16-14)10-21-15(18)22-13-7-5-12(6-8-13)17(19)20/h2-9,11H,10H2,1H3
• InChIKey: AFINOVIFQZMCHN-UHFFFAOYSA-N
• SMILES: CC(COC(=O)OC1=CC=C(C=C1)[N+](=O)[O-])SSC2=CC=CC=N2

PPC-NB(CAT: I046043) is a glutathione-cleavable linker designed for use in antibody–drug conjugates (ADCs). Incorporating a disulfide bond, PPC-NB remains stable in systemic circulation but undergoes selective cleavage in the reductive intracellular environment, triggered by elevated glutathione concentrations within tumor cells. This mechanism ensures precise intracellular release of cytotoxic payloads, enhancing therapeutic efficacy while minimizing off-target toxicity. PPC-NB provides versatility for conjugation with a wide range of drug molecules, making it a valuable tool for ADC development and optimization. It supports research into targeted cancer therapies by enabling controlled drug delivery and linker–payload system evaluation.