For research use only. Not for therapeutic Use.
Pozanicline dihydrochloride (CAT: R036177) is an orally bioavailable and selective nicotinic acetylcholine receptor (nAChR) agonist with high affinity for α4β2 receptors (Ki = 16.7 nM at [³H]cytisine sites). It binds rat brain α4β2 nAChRs with a Ki of 17 nM, showing minimal activity at α7 receptors. As a partial agonist, Pozanicline exhibits high selectivity for α6β2 and α4α5β2 subtypes, with notable potency at α6β2 (EC50 = 0.11 μM). In vivo, Pozanicline (0.3–0.6 mg/kg) reverses nicotine withdrawal-induced cognitive deficits, highlighting its utility in neuropharmacology, cognition, addiction, and neurological disease research.
| CAS Number | 161416-61-1 |
| Synonyms | 2-methyl-3-[[(2S)-pyrrolidin-2-yl]methoxy]pyridine;dihydrochloride |
| Molecular Formula | C11H18Cl2N2O |
| Purity | ≥95% |
| IUPAC Name | 2-methyl-3-[[(2S)-pyrrolidin-2-yl]methoxy]pyridine;dihydrochloride |
| InChI | InChI=1S/C11H16N2O.2ClH/c1-9-11(5-3-6-12-9)14-8-10-4-2-7-13-10;;/h3,5-6,10,13H,2,4,7-8H2,1H3;2*1H/t10-;;/m0../s1 |
| InChIKey | UGVSESCRKJTJAK-XRIOVQLTSA-N |
| SMILES | CC1=C(C=CC=N1)OCC2CCCN2.Cl.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
