For research use only. Not for therapeutic Use.
Posovolone（Cat No.:I045242）is a synthetic neuroactive steroid and positive allosteric modulator of GABAA_A receptors, enhancing inhibitory neurotransmission in the central nervous system. By binding to specific sites on GABAA_A receptors, it increases the receptor’s response to GABA without directly activating the channel, leading to sedative, anxiolytic, and anticonvulsant effects. Posovolone’s mechanism makes it a promising candidate for research into epilepsy, anxiety disorders, and insomnia. Its selectivity and potency offer potential advantages over traditional benzodiazepines, providing a valuable tool for studying GABAergic modulation and the development of novel CNS-targeted therapeutics.
| CAS Number | 256955-84-7 |
| Synonyms | 1-[(3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-3-(methoxymethyl)-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2-imidazol-1-ylethanone |
| Molecular Formula | C26H40N2O3 |
| Purity | ≥95% |
| IUPAC Name | 1-[(3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-3-(methoxymethyl)-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2-imidazol-1-ylethanone |
| InChI | InChI=1S/C26H40N2O3/c1-24-10-11-26(30,16-31-3)14-18(24)4-5-19-20-6-7-22(25(20,2)9-8-21(19)24)23(29)15-28-13-12-27-17-28/h12-13,17-22,30H,4-11,14-16H2,1-3H3/t18-,19-,20-,21-,22+,24-,25-,26+/m0/s1 |
| InChIKey | BRVGKZNQWCQKTC-MVCIVNJCSA-N |
| SMILES | C[C@]12CC[C@@](C[C@@H]1CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@@H]4C(=O)CN5C=CN=C5)C)(COC)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
