For research use only. Not for therapeutic Use.
Ponatinib hydrochloride（Cat No.:I008827）is a potent, oral tyrosine kinase inhibitor used primarily in the treatment of chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL), particularly in cases resistant to other therapies. It works by inhibiting multiple tyrosine kinases, including BCR-ABL, the protein responsible for the malignant transformation of CML cells. Ponatinib hydrochloride is effective against mutations such as T315I, which confers resistance to other tyrosine kinase inhibitors. It is an important treatment option for patients with refractory or resistant leukemia, offering a new avenue for managing these challenging cancers.
| CAS Number | 1114544-31-8 |
| Synonyms | 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide;hydrochloride |
| Molecular Formula | C29H28ClF3N6O |
| Purity | ≥95% |
| IUPAC Name | 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide;hydrochloride |
| InChI | InChI=1S/C29H27F3N6O.ClH/c1-20-5-6-22(16-21(20)8-10-25-18-33-27-4-3-11-34-38(25)27)28(39)35-24-9-7-23(26(17-24)29(30,31)32)19-37-14-12-36(2)13-15-37;/h3-7,9,11,16-18H,12-15,19H2,1-2H3,(H,35,39);1H |
| InChIKey | BWTNNZPNKQIADY-UHFFFAOYSA-N |
| SMILES | CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
