Ponatinib - CAS 943319-70-8
Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.
AP24534 potently inhibits native Abl, Abl
In a mouse xenograft model of Ba/F3 cells expressing native Bcr-Abl, AP24534 (2.5 mg/kg and 5 mg/kg) prolongs mice median survival. In the xenograft model of Ba/F3 Bcr-Abl
Catalog Number: A001082
CAS Number: 943319-70-8
PubChem Substance ID:354326214
Molecular Formula: C₂₉H₂₇F₃N₆O
Molecular Weight:532.56
Purity: ≥95%
* For research use only. Not for human or veterinary use.
Synonym
Synonyms | NA |
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Property
Molecular Formula: | C₂₉H₂₇F₃N₆O |
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Molecular Weight | 532.56 |
Target: | Bcr-Abl |
Solubility | Soluble in DMSO > 10 mM |
Purity | ≥95% |
Storage | 3 years -20C powder |
MDL | MFCD17215203 |
Computed Descriptor
InChI | InChI=1S/C29H27F3N6O/c1-20-5-6-22(16-21(20)8-10-25-18-33-27-4-3-11-34-38(25)27)28(39)35-24-9-7-23(26(17-24)29(30,31)32)19-37-14-12-36(2)13-15-37/h3-7,9,11,16-18H,12-15,19H2,1-2H3,(H,35,39) |
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InChIKey | PHXJVRSECIGDHY-UHFFFAOYSA-N |
SMILES | CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5 |