Ponatinib - CAS 943319-70-8

Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.
AP24534 potently inhibits native Abl, Abl
In a mouse xenograft model of Ba/F3 cells expressing native Bcr-Abl, AP24534 (2.5 mg/kg and 5 mg/kg) prolongs mice median survival. In the xenograft model of Ba/F3 Bcr-Abl

Catalog Number: A001082

CAS Number: 943319-70-8

PubChem Substance ID:354326214

Molecular Formula: C₂₉H₂₇F₃N₆O

Molecular Weight:532.56

Purity: ≥95%

* For research use only. Not for human or veterinary use.

Synonym

• Synonyms: NA

Property

• Molecular Formula: C₂₉H₂₇F₃N₆O
• Molecular Weight: 532.56
• Target: Bcr-Abl
• Solubility: Soluble in DMSO > 10 mM
• Purity: ≥95%
• Storage: 3 years -20C powder
• MDL: MFCD17215203

Computed Descriptor

• InChI: InChI=1S/C29H27F3N6O/c1-20-5-6-22(16-21(20)8-10-25-18-33-27-4-3-11-34-38(25)27)28(39)35-24-9-7-23(26(17-24)29(30,31)32)19-37-14-12-36(2)13-15-37/h3-7,9,11,16-18H,12-15,19H2,1-2H3,(H,35,39)
• InChIKey: PHXJVRSECIGDHY-UHFFFAOYSA-N
• SMILES: CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5