Pomalidomide-PEG6-NH2 hydrochloride

• CAT Number: I015249
• CAS Number: 2341841-01-6
• Molecular Formula: C25H36ClN3O10
• Molecular Weight: 574.02
• Purity: ≥95%
• Synonyms: 4-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;hydrochloride
• InChI: InChI=1S/C25H35N3O10.ClH/c26-6-7-33-8-9-34-10-11-35-12-13-36-14-15-37-16-17-38-20-3-1-2-18-22(20)25(32)28(24(18)31)19-4-5-21(29)27-23(19)30;/h1-3,19H,4-17,26H2,(H,27,29,30);1H
• InChIKey: MWEFMNTVJQCCJU-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)OCCOCCOCCOCCOCCOCCN.Cl

Pomalidomide-PEG6-NH2 hydrochloride（Cat No.:I015249）is a thalidomide derivative modified with a six-unit polyethylene glycol (PEG6) spacer terminating in an amine group, supplied as a hydrochloride salt. This bifunctional linker combines the immunomodulatory properties of pomalidomide with enhanced aqueous solubility and reactive handle flexibility. It is commonly used in the design of PROTACs, antibody-drug conjugates, and other targeted drug delivery systems. The PEG6 chain provides improved pharmacokinetics and reduced steric hindrance, facilitating conjugation efficiency in chemical biology and medicinal chemistry research applications.