Pomalidomide-PEG2-COOH

• CAT Number: I033700
• CAS Number: 2140807-17-4
• Molecular Formula: C20H23N3O8
• Molecular Weight: 433.41
• Purity: ≥95%
• Synonyms: 3-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]propanoic acid
• InChI: InChI=1S/C20H23N3O8/c24-15-5-4-14(18(27)22-15)23-19(28)12-2-1-3-13(17(12)20(23)29)21-7-9-31-11-10-30-8-6-16(25)26/h1-3,14,21H,4-11H2,(H,25,26)(H,22,24,27)
• InChIKey: NKISJPXMSOQWER-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCOCCOCCC(=O)O

Pomalidomide-PEG2-COOH (Cat No.: I033700) is a functionalized pomalidomide derivative featuring a polyethylene glycol spacer with two ethylene glycol units (PEG2) terminating in a carboxylic acid group. The pomalidomide moiety binds cereblon (CRBN), an E3 ubiquitin ligase substrate receptor, enabling recruitment of target proteins for ubiquitination and proteasomal degradation in PROTAC (proteolysis-targeting chimera) constructs. The PEG2 linker enhances solubility, flexibility, and reduces steric hindrance, while the terminal carboxylic acid provides a conjugation site. This reagent is widely used in targeted protein degradation research and drug discovery applications.

Reference

[1]. Fangqing Zhang, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228.
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