Pomalidomide-amino-PEG5-NH2 hydrochloride

• CAT Number: I045306
• CAS Number: 2421217-05-0
• Molecular Formula: C25H35ClN4O10
• Molecular Weight: 587.02
• Purity: ≥95%
• Synonyms: 2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]-N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]acetamide;hydrochloride
• InChI: InChI=1S/C25H34N4O10.ClH/c26-6-7-35-8-9-36-10-11-37-12-13-38-14-15-39-16-21(31)27-18-3-1-2-17-22(18)25(34)29(24(17)33)19-4-5-20(30)28-23(19)32;/h1-3,19H,4-16,26H2,(H,27,31)(H,28,30,32);1H
• InChIKey: VQFIXEMZYHCOIK-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NC(=O)COCCOCCOCCOCCOCCN.Cl

Pomalidomide-amino-PEG5-NH2 hydrochloride（Cat No.:I045306）is a pomalidomide-based cereblon (CRBN) ligand functionalized with a polyethylene glycol (PEG5) spacer ending in a primary amine, provided as a hydrochloride salt for enhanced solubility and stability. The pomalidomide moiety recruits the CRBN E3 ubiquitin ligase complex, enabling targeted protein degradation in PROTAC and molecular glue designs. The PEG5 linker offers increased length, flexibility, and hydrophilicity, improving target engagement and pharmacokinetic properties. This versatile bifunctional reagent is widely used in medicinal chemistry and chemical biology to develop next-generation therapeutics based on selective protein degradation strategies.