For research use only. Not for therapeutic Use.
Pomalidomide-amino-PEG4-NH2 hydrochloride（Cat No.:I044466）is a functionalized derivative of pomalidomide, an immunomodulatory drug (IMiD) used as a ligand for the cereblon (CRBN) E3 ubiquitin ligase in PROTAC (proteolysis-targeting chimera) design. It incorporates a PEG4 (polyethylene glycol) linker with a terminal amine group, enabling conjugation to a protein-targeting ligand. The hydrochloride salt enhances solubility and stability for chemical synthesis. This compound retains CRBN-binding activity while providing flexible spacing and reactivity for constructing bifunctional molecules. It is a valuable tool in targeted protein degradation research and therapeutic development in oncology and beyond.
| CAS Number | 2331259-45-9 |
| Synonyms | 2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]-N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]acetamide;hydrochloride |
| Molecular Formula | C23H31ClN4O9 |
| Purity | ≥95% |
| IUPAC Name | 2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]-N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]acetamide;hydrochloride |
| InChI | InChI=1S/C23H30N4O9.ClH/c24-6-7-33-8-9-34-10-11-35-12-13-36-14-19(29)25-16-3-1-2-15-20(16)23(32)27(22(15)31)17-4-5-18(28)26-21(17)30;/h1-3,17H,4-14,24H2,(H,25,29)(H,26,28,30);1H |
| InChIKey | HFCHLXYVKQEGTC-UHFFFAOYSA-N |
| SMILES | C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NC(=O)COCCOCCOCCOCCN.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
