Pomalidomide-amido-C5-PEG2-C6-chlorine

• CAT Number: I040629
• CAS Number: 1835705-69-5
• Molecular Formula: C29H40ClN3O8
• Molecular Weight: 594.10
• Purity: ≥95%
• Synonyms: 6-[2-[2-(6-chlorohexoxy)ethoxy]ethoxy]-N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]hexanamide
• InChI: InChI=1S/C29H40ClN3O8/c30-14-5-1-2-6-15-39-17-19-41-20-18-40-16-7-3-4-11-24(34)31-22-10-8-9-21-26(22)29(38)33(28(21)37)23-12-13-25(35)32-27(23)36/h8-10,23H,1-7,11-20H2,(H,31,34)(H,32,35,36)
• InChIKey: CEGOWZXGBJKMOC-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NC(=O)CCCCCOCCOCCOCCCCCCCl

Pomalidomide-amido-C5-PEG2-C6-chlorine(CAT: I040629) is a versatile E3 ligase ligand-linker conjugate used in the design of PROTACs (proteolysis-targeting chimeras). Featuring a pomalidomide moiety for cereblon (CRBN) recruitment, a PEG-based linker (C5-PEG2-C6) for optimal spatial flexibility, and a reactive chlorine handle for conjugation, this compound enables efficient assembly of bifunctional degraders targeting disease-relevant proteins. Its structure supports enhanced solubility, cellular permeability, and precise protein–ligase engagement. Widely applied in targeted protein degradation research, it aids in the development of novel therapeutics for cancer, autoimmune, and neurodegenerative diseases.