Pomalidomide-amido-C1-Br

• CAT Number: I017381
• CAS Number: 2351106-38-0
• Molecular Formula: C15H12BrN3O5
• Molecular Weight: 394.18
• Purity: ≥95%
• Synonyms: 2-bromo-N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]acetamide
• InChI: InChI=1S/C15H12BrN3O5/c16-6-11(21)17-8-3-1-2-7-12(8)15(24)19(14(7)23)9-4-5-10(20)18-13(9)22/h1-3,9H,4-6H2,(H,17,21)(H,18,20,22)
• InChIKey: VFHGCZZAGNKHIX-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NC(=O)CBr

Pomalidomide-amido-C1-Br(CAT:I017381) is a functionalized pomalidomide-based cereblon (CRBN) E3 ligase ligand–linker conjugate designed for PROTAC (proteolysis-targeting chimera) synthesis. Incorporating the CRBN-binding pomalidomide moiety with a short C1-bromoalkyl linker, this bifunctional intermediate enables conjugation with target ligands to recruit CRBN for ubiquitination and proteasomal degradation of specific proteins. Retaining the high binding affinity of pomalidomide for cereblon, Pomalidomide-amido-C1-Br serves as a versatile building block in targeted protein degradation research. It is an essential chemical biology tool for designing next-generation PROTACs in oncology, immunology, and epigenetics, accelerating the development of novel therapeutic strategies.