Pomalidomide-5-C9-NH2 hydrochloride

• CAT Number: I040586
• CAS Number: 2925306-22-3
• Molecular Formula: C22H31ClN4O4
• Molecular Weight: 450.96
• Purity: ≥95%
• Synonyms: 5-(9-aminononylamino)-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;hydrochloride
• InChI: InChI=1S/C22H30N4O4.ClH/c23-12-6-4-2-1-3-5-7-13-24-15-8-9-16-17(14-15)22(30)26(21(16)29)18-10-11-19(27)25-20(18)28;/h8-9,14,18,24H,1-7,10-13,23H2,(H,25,27,28);1H
• InChIKey: ZBVVNKGSJSMFOZ-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C=C(C=C3)NCCCCCCCCCN.Cl

Pomalidomide-5-C9-NH2 hydrochloride(CAT: I040586) is a cereblon-binding pomalidomide analog equipped with a nonylamine (C9) linker at the 5-position, designed for constructing PROTACs and other bifunctional degraders. The nine-carbon chain provides an optimal balance of flexibility and reach, supporting effective spatial arrangement between the E3 ligase-binding moiety and the target ligand. This compound is ideal for researchers developing targeted protein degradation strategies where linker length plays a critical role in efficacy and selectivity. Pomalidomide-5-C9-NH2 hydrochloride is widely used in medicinal chemistry and chemical biology applications focused on modulating protein homeostasis through cereblon-mediated ubiquitination.