Pomalidomide-5-C12-NH2 hydrochloride

• CAT Number: I040293
• Molecular Formula: C25H37ClN4O4
• Molecular Weight: 493.04
• Purity: ≥95%
• Synonyms: 5-(12-aminododecylamino)-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;hydrochloride
• InChI: InChI=1S/C25H36N4O4.ClH/c26-15-9-7-5-3-1-2-4-6-8-10-16-27-18-11-12-19-20(17-18)25(33)29(24(19)32)21-13-14-22(30)28-23(21)31;/h11-12,17,21,27H,1-10,13-16,26H2,(H,28,30,31);1H
• InChIKey: OJPOYIIDYYDEGW-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C=C(C=C3)NCCCCCCCCCCCCN.Cl

Pomalidomide-5-C12-NH₂ hydrochloride(CAT: I040293) is a pomalidomide-derived cereblon (CRBN) ligand functionalized with a 12-carbon alkylamino linker at the 5-position. Designed for use in PROTAC (proteolysis-targeting chimera) technology, this compound enables recruitment of the CRBN E3 ubiquitin ligase to facilitate targeted protein ubiquitination and degradation. The C12 linker provides an optimal balance of flexibility and reach for conjugation to various target ligands. Supplied as a hydrochloride salt to enhance solubility and chemical stability, Pomalidomide-5-C12-NH₂ HCl is a valuable intermediate for developing selective degraders in oncology, immunology, and neurodegenerative disease research.