Pomalidomide-5-C11-NH2 hydrochloride

• CAT Number: I040294
• Molecular Formula: C24H35ClN4O4
• Molecular Weight: 479.01
• Purity: ≥95%
• Synonyms: 5-(11-aminoundecylamino)-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;hydrochloride
• InChI: InChI=1S/C24H34N4O4.ClH/c25-14-8-6-4-2-1-3-5-7-9-15-26-17-10-11-18-19(16-17)24(32)28(23(18)31)20-12-13-21(29)27-22(20)30;/h10-11,16,20,26H,1-9,12-15,25H2,(H,27,29,30);1H
• InChIKey: PBUSIUNWHXRGHK-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C=C(C=C3)NCCCCCCCCCCCN.Cl

Pomalidomide-5-C11-NH₂ hydrochloride(CAT: I040294) is a cereblon (CRBN)-recruiting ligand derived from pomalidomide, functionalized with an 11-carbon alkylamino linker at the 5-position. This compound is specifically designed for use in PROTAC (proteolysis-targeting chimera) synthesis, where it enables targeted protein degradation by bridging CRBN with a protein-specific ligand. The C11 linker provides suitable spatial flexibility for efficient ternary complex formation and ubiquitin-proteasome-mediated degradation. Supplied as a hydrochloride salt for improved solubility and handling, Pomalidomide-5-C11-NH₂ HCl is a valuable building block for the development of selective degraders in cancer, immunology, and neurodegenerative disease research.