Pomalidomide-5-C10-NH2 hydrochloride

• CAT Number: I040585
• CAS Number: 2863635-00-9
• Molecular Formula: C23H33ClN4O4
• Molecular Weight: 464.99
• Purity: ≥95%
• Synonyms: 5-(10-aminodecylamino)-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;hydrochloride
• InChI: InChI=1S/C23H32N4O4.ClH/c24-13-7-5-3-1-2-4-6-8-14-25-16-9-10-17-18(15-16)23(31)27(22(17)30)19-11-12-20(28)26-21(19)29;/h9-10,15,19,25H,1-8,11-14,24H2,(H,26,28,29);1H
• InChIKey: DIKVPOWBHZTVTH-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C=C(C=C3)NCCCCCCCCCCN.Cl

Pomalidomide-5-C10-NH2 hydrochloride(CAT: I040585) is a functionalized derivative of pomalidomide featuring a decylamine (C10) linker at the 5-position, tailored for use in the synthesis of cereblon-recruiting PROTACs and other targeted protein degraders. The extended alkyl chain offers flexible spatial orientation for attaching ligands or payloads without disrupting cereblon binding. This compound enables precise construction of heterobifunctional molecules for studying E3 ligase-mediated ubiquitination and degradation pathways. Its long linker is advantageous in cases where distal warhead positioning improves degradation efficiency or selectivity. Pomalidomide-5-C10-NH2 hydrochloride is a versatile intermediate for medicinal chemistry, chemical biology, and targeted therapeutics research.