Pomalidomide 4'-PEG5-acid

• CAT Number: I035218
• CAS Number: 2139348-63-1
• Molecular Formula: C26H35N3O11
• Molecular Weight: 565.57
• Purity: ≥95%
• Synonyms: 3-[2-[2-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
• InChI: InChI=1S/C26H35N3O11/c30-21-5-4-20(24(33)28-21)29-25(34)18-2-1-3-19(23(18)26(29)35)27-7-9-37-11-13-39-15-17-40-16-14-38-12-10-36-8-6-22(31)32/h1-3,20,27H,4-17H2,(H,31,32)(H,28,30,33)
• InChIKey: PMCQLKMOQUEEDR-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCOCCOCCOCCOCCOCCC(=O)O

Pomalidomide 4′-PEG5-acid (Cat No.: I035218) is a functionalized pomalidomide derivative featuring a polyethylene glycol spacer with five ethylene glycol units (PEG5) terminating in a carboxylic acid group at the 4′-position. The pomalidomide moiety binds cereblon (CRBN), an E3 ubiquitin ligase substrate receptor, enabling recruitment of target proteins for ubiquitination and proteasomal degradation in PROTAC (proteolysis-targeting chimera) applications. The PEG5 linker enhances solubility, flexibility, and reduces steric hindrance, while the terminal acid serves as a conjugation handle for ligand attachment in targeted protein degradation research and drug discovery.

Reference

[1]. [1]Jing Liu, et al. Cyclic-amp response element binding protein (cbp) and/or adenoviral e1a binding protein of 300 kda (p300) degradation compounds and methods of use. WO2020173440A1.