For research use only. Not for therapeutic Use.
Pomalidomide 4′-PEG2-azide (Cat No.: I023803) is a functionalized derivative of pomalidomide, featuring a polyethylene glycol (PEG2) linker and terminal azide group. This modification enables bioorthogonal conjugation via click chemistry, making it valuable in the design of PROTACs (proteolysis-targeting chimeras) and other drug discovery applications. The pomalidomide core retains its ability to bind cereblon, an E3 ubiquitin ligase substrate receptor, while the PEG2-azide moiety provides spatial flexibility and modularity for targeted protein degradation strategies in cancer and immunomodulatory research.
| CAS Number | 2271036-45-2 |
| Synonyms | 4-[2-[2-(2-azidoethoxy)ethoxy]ethylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione |
| Molecular Formula | C19H22N6O6 |
| Purity | ≥95% |
| InChI | InChI=1S/C19H22N6O6/c20-24-22-7-9-31-11-10-30-8-6-21-13-3-1-2-12-16(13)19(29)25(18(12)28)14-4-5-15(26)23-17(14)27/h1-3,14,21H,4-11H2,(H,23,26,27) |
| InChIKey | BBYXCRBBKSBKOA-UHFFFAOYSA-N |
| SMILES | C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCOCCOCCN=[N+]=[N-] |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
