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Polyquaternium-1

Polyquaternium-1

  • CAT Number: R057476
  • CAS Number: 75345-27-6
  • Molecular Formula: (C₆H₁₂ClN)n C₁₆H₃₆Cl₂N₂O₆
  • Purity: ≥95%
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Polyquaternium-1 (Cat. No: R057476) is an antimicrobial preservative used for rabbit ocular surface study on polyquad-preserved travoprost/timolol, benzalkonium chloride-preserved travoprost/timolol, and latanoprost/timolol in fixed combinations.Ethanol, 2,2′,2″ -nitrilotris-, polymer with 1,4-dichloro-2-butene and N,N,N′,N′-tetramethyl-2-butene-1,4-diamine.

Catalog Number R057476
CAS Number 75345-27-6
Synonyms

α-[4-[Tris(2-hydroxyethyl)ammonio]-2-buten-1-yl]-ω-[tris(2-hydroxyethyl)ammonio]poly[(dimethyliminio)-2-butene-1,4-diyl Chloride] Chloride; Onamer M; Onyxsperse 12S; Polidronium Chloride; Polyquad; Polyquat 1;

Molecular Formula

(C₆H₁₂ClN)n C₁₆H₃₆Cl₂N₂O₆

Purity 95%
Storage -20°C
IUPAC Name dimethyl-bis[(E)-4-[tris(2-hydroxyethyl)azaniumyl]but-2-enyl]azanium;trichloride
InChI InChI=1S/C22H48N3O6.3ClH/c1-23(2,7-3-5-9-24(11-17-26,12-18-27)13-19-28)8-4-6-10-25(14-20-29,15-21-30)16-22-31;;;/h3-6,26-31H,7-22H2,1-2H3;3*1H/q+3;;;/p-3/b5-3+,6-4+;;;
InChIKey OTIWYSKRSMXGNK-VHJGTCNUSA-K
SMILES C[N+](C)(CC=CC[N+](CCO)(CCO)CCO)CC=CC[N+](CCO)(CCO)CCO.[Cl-].[Cl-].[Cl-]
Reference

1. Cornea. 2019 Apr;38(4):502-503. doi: 10.1097/ICO.0000000000001885.<br />
Polyquaternium-1-Associated Dendritiform Keratopathy.<br />
Verkade A(1), Matoba AY.<br />
DOI: 10.1097/ICO.0000000000001885 PMID: 30702469<br />
<br />
2. Expert Opin Drug Deliv. 2011 Nov;8(11):1425-38. doi: 10.1517/17425247.2011.617736. Epub 2011 Sep 9.<br />
Ophthalmic preservatives: focus on polyquaternium-1.<br />
Rolando M(1), Crider JY, Kahook MY.<br />
DOI: 10.1517/17425247.2011.617736 PMID: 21905766<br />
<br />
3. Am J Ophthalmol. 2015 Aug;160(2):266-274.e1. doi: 10.1016/j.ajo.2015.04.041. Epub 2015 Apr 30.<br />
Polyquaternium-1-Preserved Travoprost 0.003% or Benzalkonium Chloride-Preserved Travoprost 0.004% for Glaucoma and Ocular Hypertension.<br />
Peace JH(1), Ahlberg P(2), Wagner M(3), Lim JM(4), Wirta D(5), Branch JD(6).<br />
DOI: 10.1016/j.ajo.2015.04.041 PMID: 25935098

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