Polyinosinic-polycytidylic Acid (potassium salt) - CAS 31852-29-6

Polyinosinic-polycytidylic acid (poly(I:C)) is a synthetic double-stranded RNA (dsRNA) that activates toll-like receptor 3 and retinoic acid inducible gene 1 (RIG-1)-like receptors, including RIG-1 and melanoma differentiation associated gene 5. Through these actions, poly(I:C) activates NF-κB, induces IFN-α, promotes dendritic cell maturation, and stimulates both innate and adaptive immunity. As poly(I:C) imitates dsRNA found in some viral genomes, it bolsters immune defense against certain viruses. Poly(I:C) also directly triggers apoptosis in some cancer cells.

Catalog Number: R065371

CAS Number: 31852-29-6

PubChem Substance ID:355196119

Molecular Formula: C19H27KN7O16P2

Molecular Weight:710.504

Purity: ≥95%

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Synonym

Synonyms	Poly(I:C)

Property

Molecular Formula:	C19H27KN7O16P2
Molecular Weight	710.504
Purity	≥95%
Storage	-20°C

Computed Descriptor

IUPAC Name	[(2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate;[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-3H-purin-9-yl)oxolan-2-yl]methyl dihydrogen phosphate;potassium
InChI	InChI=1S/C10H13N4O8P.C9H14N3O8P.K/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17;10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18;/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20);1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18);/t4-,6-,7-,10-;4-,6-,7-,8-;/m11./s1
InChIKey	KHPUABRWHJGXNJ-VRQAYDGLSA-N
SMILES	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O.[K]