Podocarpic acid

• CAT Number: I004228
• CAS Number: 5947-49-9
• Molecular Formula: C17H22O3
• Molecular Weight: 274.35
• Purity: ≥95%
• Synonyms: 12-hydroxypodocarpa-8,11,13-trien-16-oic acid
• Target: TRPA1
• Solubility: DMSO
• Storage: Room temperature
• IUPAC Name: (1S,4aS,10aR)-6-hydroxy-1,4a-dimethyl-2,3,4,9,10,10a-hexahydrophenanthrene-1-carboxylic acid
• InChI: InChI=1S/C17H22O3/c1-16-8-3-9-17(2,15(19)20)14(16)7-5-11-4-6-12(18)10-13(11)16/h4,6,10,14,18H,3,5,7-9H2,1-2H3,(H,19,20)/t14-,16-,17+/m1/s1
• InChIKey: VJILEYKNALCDDV-OIISXLGYSA-N
• SMILES: CC12CCCC(C1CCC3=C2C=C(C=C3)O)(C)C(=O)O

Podocarpic acid (CAT: I004228) is a naturally occurring compound that exhibits a wide range of positive effects. It is recognized as a novel activator of the TRPA1 (Transient Receptor Potential Ankyrin 1) channel. TRPA1 is a sensory receptor involved in pain and inflammation pathways. Podocarpic acid’s activation of TRPA1 suggests its potential in modulating pain perception and inflammatory responses. As a natural product, podocarpic acid holds promise as a valuable compound for further investigation and development in the field of pain management and potentially other therapeutic applications.

Reference

[1]. Baraka HN. Microbial transformation of podocarpic acid and evaluation of transformation products for antioxidant activity. Planta Med. 2010 May;76(8):815-7.
[2]. Singh S, et al. Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters. Bioorg Med Chem Lett. 2005 Jun 2;15(11):2824-8.
[3]. He W, et al. Novel cytokine release inhibitors. Part IV: analogs of podocarpic acid. Bioorg Med Chem Lett. 1999 Feb 8;9(3):469-74.
[4]. Chaudhuri J, et al. A Caenorhabditis elegans Model Elucidates a Conserved Role for TRPA1-Nrf Signaling in Reactive α-Dicarbonyl Detoxification. Curr Biol. 2016 Nov 21;26(22):3014-3025.