PND-1186 - CAS 1061353-68-1

PND-1186 (CAT: I000311) is a potent FAK (focal adhesion kinase) inhibitor that has been developed as an anti-tumor drug for cancer therapy. In vitro studies have shown that PND-1186 inhibits FAK phosphorylation, leading to the inhibition of cell movement and the promotion of cell apoptosis in breast carcinoma cells. It has demonstrated limited effects on cell proliferation but has shown efficacy in blocking tumor growth and metastasis in vivo. PND-1186 has been well-tolerated in preclinical studies, and clinical trials are being conducted to evaluate its safety and efficacy in patients with metastatic non-hematological malignancies.

Catalog Number: I000311

CAS Number: 1061353-68-1

PubChem Substance ID:355039485

Molecular Formula: C25H26F3N5O3

Molecular Weight:501.5

Purity: ≥95%

* For research use only. Not for human or veterinary use.

Synonym

Synonyms2-((2-((2-methoxy-4-morpholinophenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide

Property

Molecular Formula: C25H26F3N5O3
Molecular Weight501.5
Target:FAK
SolubilityDMSO: ≥ 34 mg/mL
Purity≥95%
StorageStore at -20°C
Overview of Clinical Research<p> <span style=”font-family:arial,helvetica,sans-serif;”><span style=”font-size:12px;”><span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>PND-1186 is under investigation in clinical trial NCT02215629 (Dose Escalation Study in Acute Myeloid or B-Cell Acute Lymphoblastic Leukemia).</span></span></span></p>
IC501.5 nM

Computed Descriptor

IUPAC Name2-[[2-(2-methoxy-4-morpholin-4-ylanilino)-5-(trifluoromethyl)pyridin-4-yl]amino]-N-methylbenzamide
InChIInChI=1S/C25H26F3N5O3/c1-29-24(34)17-5-3-4-6-19(17)31-21-14-23(30-15-18(21)25(26,27)28)32-20-8-7-16(13-22(20)35-2)33-9-11-36-12-10-33/h3-8,13-15H,9-12H2,1-2H3,(H,29,34)(H2,30,31,32)
InChIKeyIGUBBWJDMLCRIK-UHFFFAOYSA-N
SMILESCNC(=O)C1=CC=CC=C1NC2=CC(=NC=C2C(F)(F)F)NC3=C(C=C(C=C3)N4CCOCC4)OC