For research use only. Not for therapeutic Use.
PND-1186 hydrochloride (Cat No.:I044439) is a potent and selective inhibitor of focal adhesion kinase (FAK), a non-receptor tyrosine kinase involved in cell adhesion, migration, survival, and cancer progression. By targeting FAK, PND-1186 hydrochloride disrupts integrin-mediated signaling and reduces tumor cell proliferation, invasion, and metastasis. It also modulates the tumor microenvironment by affecting cancer-associated fibroblasts and immune cell infiltration. This compound has shown efficacy in preclinical models of solid tumors and hematologic malignancies. PND-1186 hydrochloride is widely used in oncology research to explore FAK-targeted therapeutic strategies.
| CAS Number | 1356154-94-3 |
| Synonyms | 2-[[2-(2-methoxy-4-morpholin-4-ylanilino)-5-(trifluoromethyl)pyridin-4-yl]amino]-N-methylbenzamide;hydrochloride |
| Molecular Formula | C25H27ClF3N5O3 |
| Purity | ≥95% |
| IUPAC Name | 2-[[2-(2-methoxy-4-morpholin-4-ylanilino)-5-(trifluoromethyl)pyridin-4-yl]amino]-N-methylbenzamide;hydrochloride |
| InChI | InChI=1S/C25H26F3N5O3.ClH/c1-29-24(34)17-5-3-4-6-19(17)31-21-14-23(30-15-18(21)25(26,27)28)32-20-8-7-16(13-22(20)35-2)33-9-11-36-12-10-33;/h3-8,13-15H,9-12H2,1-2H3,(H,29,34)(H2,30,31,32);1H |
| InChIKey | OWQFAUOQRRIFLB-UHFFFAOYSA-N |
| SMILES | CNC(=O)C1=CC=CC=C1NC2=CC(=NC=C2C(F)(F)F)NC3=C(C=C(C=C3)N4CCOCC4)OC.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
