PMSF

• CAT Number: A000800
• CAS Number: 329-98-6
• Molecular Formula: C₇H₇FO₂S
• Molecular Weight: 174.20
• Purity: ≥95%
• Synonyms: Phenylmethylsulfonyl Fluoride
• Target: Cathepsin
• Solubility: Soluble in DMSO > 10 mM
• Storage: 3 years -20C powder
• IUPAC Name: phenylmethanesulfonyl fluoride
• InChI: InChI=1S/C7H7FO2S/c8-11(9,10)6-7-4-2-1-3-5-7/h1-5H,6H2
• InChIKey: YBYRMVIVWMBXKQ-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)CS(=O)(=O)F

PMSF (Cat No.:A000800) is a serine protease inhibitor with the molecular formula C7H7FO2S, widely used in biochemical and molecular biology research to prevent protein degradation during cell lysis and extraction. It irreversibly inhibits enzymes such as trypsin, chymotrypsin, and thrombin by covalently modifying the serine residue in their active sites. PMSF is a colorless to white crystalline solid, soluble in organic solvents like isopropanol or ethanol, but rapidly hydrolyzed in aqueous solutions. Due to its toxicity and volatility, PMSF must be handled with care, using protective equipment and proper ventilation during use.