PLX5622

• CAT Number: I018176
• CAS Number: 1303420-67-8
• Molecular Formula: C21H19F2N5O
• Molecular Weight: 395.41
• Purity: ≥95%
• Synonyms: 6-fluoro-N-[(5-fluoro-2-methoxypyridin-3-yl)methyl]-5-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]pyridin-2-amine
• IUPAC Name: 6-fluoro-N-[(5-fluoro-2-methoxy-3-pyridinyl)methyl]-5-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]pyridin-2-amine
• InChI: InChI=1S/C21H19F2N5O/c1-12-5-17-14(9-26-20(17)25-8-12)6-13-3-4-18(28-19(13)23)24-10-15-7-16(22)11-27-21(15)29-2/h3-5,7-9,11H,6,10H2,1-2H3,(H,24,28)(H,25,26)
• InChIKey: NSMOZFXKTHCPTQ-UHFFFAOYSA-N
• SMILES: CC1=CC2=C(NC=C2CC3=C(N=C(C=C3)NCC4=C(N=CC(=C4)F)OC)F)N=C1

PLX5622（Cat No.:I018176）is a highly selective, orally bioavailable inhibitor of colony-stimulating factor 1 receptor (CSF1R), a key regulator of microglia and macrophage survival. By blocking CSF1R signaling, PLX5622 effectively reduces microglial populations in the central nervous system, making it a powerful tool for studying neuroinflammation, neurodegeneration, and brain immune responses. Preclinical studies highlight its use in models of Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative disorders. PLX5622 is widely applied in neuroscience and immunology research to explore microglial function and immune-mediated disease mechanisms.