PLK4-IN-1

• CAT Number: I044542
• CAS Number: 1247001-12-2
• Molecular Formula: C18H14IN3O2
• Molecular Weight: 431.23
• Purity: ≥95%
• IUPAC Name: (2'S,3R)-2'-(3-iodo-2H-indazol-6-yl)-5-methoxyspiro[1H-indole-3,1'-cyclopropane]-2-one
• InChI: InChI=1S/C18H14IN3O2/c1-24-10-3-5-14-12(7-10)18(17(23)20-14)8-13(18)9-2-4-11-15(6-9)21-22-16(11)19/h2-7,13H,8H2,1H3,(H,20,23)(H,21,22)/t13-,18-/m0/s1
• InChIKey: ASLOEJIVGTXGIM-UGSOOPFHSA-N
• SMILES: COC1=CC2=C(C=C1)NC(=O)[C@@]23C[C@H]3C4=CC5=NNC(=C5C=C4)I

PLK4-IN-1（Cat No.:I044542）is a potent and selective inhibitor of Polo-like kinase 4 (PLK4), a serine/threonine kinase essential for centriole duplication and cell cycle progression. By targeting PLK4, PLK4-IN-1 disrupts centrosome integrity, leading to mitotic defects and cell death, particularly in rapidly dividing cancer cells. It exhibits high specificity and efficacy in preclinical cancer models, making it a promising candidate for anticancer therapy. PLK4-IN-1 is also a valuable tool for studying centrosome biology, spindle assembly, and genomic stability. Its mechanism highlights the therapeutic potential of targeting cell division machinery in oncology.