For research use only. Not for therapeutic Use.
PKI-179 hydrochloride (Cat No.: I045631) is a dual inhibitor of phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR), key regulators of cell survival, growth, and metabolism. By blocking these pathways, PKI-179 hydrochloride suppresses oncogenic signaling, making it valuable in cancer research. It is used to investigate tumor progression, apoptosis, and resistance mechanisms in preclinical models. While not approved for therapeutic use, PKI-179 hydrochloride provides an important pharmacological tool for studying PI3K/mTOR biology and evaluating potential strategies in oncology drug discovery.
| CAS Number | 1463510-35-1 |
| Synonyms | 1-[4-[4-morpholin-4-yl-6-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-1,3,5-triazin-2-yl]phenyl]-3-pyridin-4-ylurea;hydrochloride |
| Molecular Formula | C25H29ClN8O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C25H28N8O3.ClH/c34-25(28-19-7-9-26-10-8-19)27-18-3-1-17(2-4-18)22-29-23(32-11-13-35-14-12-32)31-24(30-22)33-20-5-6-21(33)16-36-15-20;/h1-4,7-10,20-21H,5-6,11-16H2,(H2,26,27,28,34);1H |
| InChIKey | JNMURGIZAFELTR-UHFFFAOYSA-N |
| SMILES | C1CC2COCC1N2C3=NC(=NC(=N3)N4CCOCC4)C5=CC=C(C=C5)NC(=O)NC6=CC=NC=C6.Cl |
| Reference | [1]. Venkatesan AM, et, al. PKI-179: an orally efficacious dual phosphatidylinositol-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5869-73. [2]. Rehan M. A structural insight into the inhibitory mechanism of an orally active PI3K/mTOR dual inhibitor, PKI-179 using computational approaches. J Mol Graph Model. 2015 Nov;62:226-234. |
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