PKC-theta inhibitor 1

• CAT Number: I018085
• CAS Number: 1160501-81-4
• Molecular Formula: C17H15F3N4O
• Molecular Weight: 348.32
• Purity: ≥95%
• Synonyms: [3-[3-[3-(trifluoromethyl)-2H-pyrazolo[3,4-b]pyridin-4-yl]phenyl]oxetan-3-yl]methanamine
• InChI: InChI=1S/C17H15F3N4O/c18-17(19,20)14-13-12(4-5-22-15(13)24-23-14)10-2-1-3-11(6-10)16(7-21)8-25-9-16/h1-6H,7-9,21H2,(H,22,23,24)
• InChIKey: WQSBBBAQXNAUEM-UHFFFAOYSA-N
• SMILES: C1C(CO1)(CN)C2=CC=CC(=C2)C3=CC=NC4=NNC(=C34)C(F)(F)F

PKC-theta inhibitor 1（Cat No.:I018085）is a selective small-molecule inhibitor targeting protein kinase C-theta (PKC-θ), a serine/threonine kinase predominantly expressed in T cells. PKC-θ plays a central role in T-cell receptor signaling, activating NF-κB and AP-1 pathways that regulate cytokine production and immune responses. By blocking PKC-θ activity, this inhibitor is useful in studying T-cell activation, autoimmune disease mechanisms, and transplant rejection. Its selectivity provides a valuable research tool for dissecting PKC-θ–dependent pathways and evaluating therapeutic strategies aimed at modulating immune responses while preserving general immune function.