For research use only. Not for therapeutic Use.
PK11007（Cat No.:I046075）is a small-molecule activator of the unfolded protein response (UPR) through selective modulation of the ATF6 pathway. By enhancing ATF6 signaling, PK11007 promotes the expression of protective chaperones and proteins that restore endoplasmic reticulum (ER) homeostasis. This compound is valuable for studying ER stress, proteostasis, and cellular adaptation under pathological conditions. PK11007 has been investigated for potential therapeutic applications in neurodegenerative diseases, cardiovascular disorders, and metabolic syndromes linked to protein misfolding. Its ability to fine-tune UPR signaling makes it a powerful tool in stress biology research.
| CAS Number | 874146-69-7 |
| Synonyms | 5-chloro-2-[(4-fluorophenyl)methylsulfonyl]-N-(5-methyl-1,3,4-thiadiazol-2-yl)pyrimidine-4-carboxamide |
| Molecular Formula | C15H11ClFN5O3S2 |
| Purity | ≥95% |
| IUPAC Name | 5-chloro-2-[(4-fluorophenyl)methylsulfonyl]-N-(5-methyl-1,3,4-thiadiazol-2-yl)pyrimidine-4-carboxamide |
| InChI | InChI=1S/C15H11ClFN5O3S2/c1-8-21-22-14(26-8)20-13(23)12-11(16)6-18-15(19-12)27(24,25)7-9-2-4-10(17)5-3-9/h2-6H,7H2,1H3,(H,20,22,23) |
| InChIKey | IVZQUWCWXYFPOQ-UHFFFAOYSA-N |
| SMILES | CC1=NN=C(S1)NC(=O)C2=NC(=NC=C2Cl)S(=O)(=O)CC3=CC=C(C=C3)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
