Pitstop 2

• CAT Number: I045575
• CAS Number: 1419320-73-2
• Molecular Formula: C20H13BrN2O3S2
• Molecular Weight: 473.36
• Purity: ≥95%

Pitstop 2 (Cat No.: I045575) is a small-molecule inhibitor that selectively targets clathrin-mediated endocytosis by binding to the terminal domain of clathrin heavy chain. Through this interaction, it prevents the recruitment of adaptor proteins required for coated pit formation, effectively blocking vesicle internalization. Pitstop 2 is widely used as a research tool to study membrane trafficking, receptor-mediated endocytosis, and intracellular signaling pathways. Its reversible inhibition allows temporal control of endocytic processes, making it valuable in dissecting clathrin-dependent mechanisms in cellular physiology.

Reference

[1]. Kumar GA, et, al. Leishmania donovani Internalizes into Host Cells via Caveolin-mediated Endocytosis. Sci Rep. 2019 Sep 2; 9(1): 12636.
[Content Brief]

[2]. Smith CM, et, al. Inhibition of clathrin by pitstop 2 activates the spindle assembly checkpoint and induces cell death in dividing HeLa cancer cells. Mol Cancer. 2013 Jan 17; 12:4.
[Content Brief]