For research use only. Not for therapeutic Use.
PITCOIN4(CAT: I040279) is a highly selective inhibitor of Class II alpha phosphoinositide 3-kinase (PI3K-C2α), demonstrating nanomolar potency and over 100-fold selectivity against a broad panel of kinases. By specifically targeting PI3K-C2α, PITCOIN4 provides a powerful tool to dissect the unique roles of Class II PI3Ks in cellular trafficking, membrane dynamics, and signal transduction. Its exceptional selectivity makes it ideal for minimizing off-target effects in mechanistic studies. PITCOIN4 is well-suited for exploring PI3K-C2α functions in cancer, metabolism, and neurodegeneration.
| Synonyms | 2-[2-[[2-[4-oxo-3-(2-phenylethyl)pteridin-2-yl]sulfanylacetyl]amino]-1,3-thiazol-4-yl]-N-(2-phenylpropan-2-yl)acetamide |
| Molecular Formula | C30H29N7O3S2 |
| Purity | ≥95% |
| IUPAC Name | 2-[2-[[2-[4-oxo-3-(2-phenylethyl)pteridin-2-yl]sulfanylacetyl]amino]-1,3-thiazol-4-yl]-N-(2-phenylpropan-2-yl)acetamide |
| InChI | InChI=1S/C30H29N7O3S2/c1-30(2,21-11-7-4-8-12-21)36-23(38)17-22-18-41-28(33-22)34-24(39)19-42-29-35-26-25(31-14-15-32-26)27(40)37(29)16-13-20-9-5-3-6-10-20/h3-12,14-15,18H,13,16-17,19H2,1-2H3,(H,36,38)(H,33,34,39) |
| InChIKey | WBXQHPRLMAYBJC-UHFFFAOYSA-N |
| SMILES | CC(C)(C1=CC=CC=C1)NC(=O)CC2=CSC(=N2)NC(=O)CSC3=NC4=NC=CN=C4C(=O)N3CCC5=CC=CC=C5 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
