Pirenzepine, Dihydrochloride

• CAT Number: R004749
• CAS Number: 29868-97-1
• Molecular Formula: C19H21N5O2.2HCl
• Molecular Weight: 424.33
• Purity: ≥95%
• Target: Muscarinic Receptor
• Solubility: Soluble to 100 mM in sterile water
• Storage: Store at RT

Pirenzepine Dihydrochloride is a selective antagonist for the mAChR M1 (M1 muscarinic receptor) and is reported to block presynaptic mAChR M1 as well as some reported inverse agonist activity. Pirenzepine dihydrochloride is an antimuscarinic agent that inhibits gastric secretion. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents.

Reference

1:HPLC determination of pirenzepine dihydrochloride in rabbit aqueous humor. Tu J, Li P, Yang X, Pang H.J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Aug 5;822(1-2):300-3. PMID: 16002348 2:Treatment of Campylobacter pylori gastritis: a pilot study using pirenzepine dihydrochloride (Gastrozepin) and three formulations of colloidal bismuth subcitrate (De-Nol). Morris A, Brown P, Ali MR, Lane M, Palmer R.N Z Med J. 1988 Oct 26;101(856 Pt 1):651-4. PMID: 3054641 3:[Promotion of gastrointestinal absorption of pirenzepine dihydrochloride in the rat. I]. Nakagawa H, Nishiyama K, Matsumoto S, Hamano K, Fukui Y, Goto S.Yakugaku Zasshi. 1988 Jul;108(7):669-73. Japanese. No abstract available. PMID: 3241303 4:Controlled double-blind study of the therapeutic effect of pirenzepine dihydrochloride in duodenal ulcer. Phase III study. Ishimori A, Yamagata S.Arzneimittelforschung. 1986 Jun;36(6):980-3. PMID: 3527182 5:Spectrophotometric determination of pirenzepine dihydrochloride using delta A method. Wahbi AM, Abounassif MA, el-Obeid HA, Gad-Kariem EA.Farmaco Prat. 1985 Oct;40(10):334-8. No abstract available. PMID: 3840745 6:Postprandial pancreatic exocrine secretion in dogs after oral administration of pirenzepine dihydrochloride. Madrid JA, Salido GM, Martinez de Victoria E, Mañas M, Mataix FJ.Arzneimittelforschung. 1985;35(10):1560-2. PMID: 2416323 7:Therapeutic effect of pirenzepine dihydrochloride on gastric ulcer evaluated by a double-blind controlled clinical study. Phase III study. Ishimori A, Yamagata S.Arzneimittelforschung. 1982;32(5):556-65. PMID: 7049190 8:Actions of pirenzepine-dihydrochloride (LS-519 Cl) on gastric juice secretion, gastric motility and experimental gastric ulcer. Matsuo Y, Seki A.Arzneimittelforschung. 1979;29(7):1028-35. No abstract available. PMID: 582994