For research use only. Not for therapeutic Use.
Piperidine-GNE-049-N-Boc（Cat No.:I044563）is a protected intermediate derivative of GNE-049, a selective inhibitor of bromodomain-containing protein 3 (BRD3) and BRD4 within the BET family. Featuring a piperidine moiety and a Boc (tert-butoxycarbonyl) protecting group, this compound is often used in medicinal chemistry for synthetic modification or prodrug design. The Boc group stabilizes the molecule during synthesis and can be removed under acidic conditions to reveal a reactive amine. Piperidine-GNE-049-N-Boc aids in structure-activity relationship (SAR) studies and facilitates the development of BET inhibitors for cancer and inflammatory disease research.
| CAS Number | 1936431-36-5 |
| Synonyms | tert-butyl 3-[7-(difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-1-piperidin-4-yl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxylate |
| Molecular Formula | C30H39F2N7O2 |
| Purity | ≥95% |
| IUPAC Name | tert-butyl 3-[7-(difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-1-piperidin-4-yl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxylate |
| InChI | InChI=1S/C30H39F2N7O2/c1-30(2,3)41-29(40)37-13-9-25-24(18-37)28(35-39(25)21-7-10-33-11-8-21)38-12-5-6-19-14-22(20-16-34-36(4)17-20)23(27(31)32)15-26(19)38/h14-17,21,27,33H,5-13,18H2,1-4H3 |
| InChIKey | NNCJWLPQMSOHBI-UHFFFAOYSA-N |
| SMILES | CC(C)(C)OC(=O)N1CCC2=C(C1)C(=NN2C3CCNCC3)N4CCCC5=CC(=C(C=C54)C(F)F)C6=CN(N=C6)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
